Engineered IgG1‐Fc – one fragment to bind them all
نویسندگان
چکیده
منابع مشابه
Engineered IgG1‐Fc – one fragment to bind them all
The crystallizable fragment (Fc) of the immunoglobulin class G (IgG) is a very attractive scaffold for the design of novel therapeutics due to its quality of uniting all essential antibody functions. This article reviews the functionalization of this homodimeric glycoprotein by diversification of structural loops of CH3 domains for the design of Fcabs, i.e. antigen-binding Fc proteins. It repor...
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ژورنال
عنوان ژورنال: Immunological Reviews
سال: 2016
ISSN: 0105-2896,1600-065X
DOI: 10.1111/imr.12385